About V Prakash Reddy
V Prakash Reddy
Professor
Chemistry
234 Schrenk Hall
Biography
Dr. V. Prakash Reddy is a tenured Professor of chemistry at the Missouri University of Science and Technology, Rolla, Missouri. He has received Ph.D. from Case Western Reserve University, Cleveland, Ohio, and M.Phil. from University of Hyderabad, India. He has carried out his postdoctoral research with Professor John E. Baldwin at Syracuse University and with the Nobel Laureate Professor George A. Olah at the University of Southern California. His research interests are in the cutting-edge interdisciplinary areas of synthetic and mechanistic organic and bioorganic chemistry, drug discovery toward neuronal disorders and other age-related diseases, carbocations and electrophilic reactions, superacids, and organofluorine chemistry. He has published about 100 journal articles, book chapters and two books (Elsevier Publishers).
Research
Expertise areas
Organofluorine chemistry, Synthetic and mechanistic organic chemistry, Medicinal Chemistry, Lithium Ion Batteries, Superacids, AGE Inhibitors/Breakers, Neurological disorders.
Research interests
Our research interests are in the frontier areas of organic, physical organic, and bioorganic chemistry, ranging from synthetic organic chemistry to organic and bioorganic reaction mechanisms, organofluorine chemistry, green chemistry, nonaqueous electrolytes, protein modifications, oxidative stress, superacids, carbocations, and asymmetric Friedel-Crafts reactions. Some of our recent contributions include novel synthetic methods for trifluoromethylations; selective kinase inhibitors as therapeutics for Alzheimer’s disease and other neurological disorders; AGE-inhibitors for mechanistic investigations of aging process and as potential therapeutics in various age-related diseases; and nonaqueous electrolytes and anion receptors as sustainable materials for lithium-ion batteries.
Publications
- Book: Organofluorine Chemistry: Synthesis and Applications (Elsevier), 2020 Au: Reddy, V. Prakash.
- Book: Organofluorine Chemistry in Biology and Medicine (Elsevier), 2015. Au: Reddy, V. P.
- US Patent: Preparation of Purine-Based Triazoles as Protein Kinase Inhibitors, 2015 Reddy, V. P.; Nair, N. G.; Smith, M. A.; Kudo, W.. U.S. Patent number:
US8,969,556 B2; WO 2012051296; A2 20120419; US
2010-61392237. - Reddy, V. P.; Aryal, P.; Robinson, S.; Rafiu, R.; Obrenovich, M.; Perry, G. Polyphenols in Alzheimer's Disease and in the Gut-Brain Axis.
Microorganisms 2020, 8, 199. - Obrenovich, M; Siddiqui, B.; McCloskey, B.; Reddy, V. P. The Microbiota-Gut-Brain Axis Heart Shunt; Part I: The French Paradox, Heart Disease and the Microbiota, Microorganisms, 2020, 8, 490.
- Jones, L.; Kumar, J.; , Mistry, A.; Chittoor Mana, T. S.; Perry, G.; , Reddy, V. P.; Obrenovich, M. E. The transformative possibilities of the microbiota and mycobiota for
health, disease, aging and technological innovation, Biomedicines,
2019, 7, 24; doi:10.3390/biomedicines7020024. - Reddy, V. P.; Perambuduru, M. Mehta, N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of
Aromatic N Tosylaldimines, Top. Catal. 2018, 61, 699-703. - Reddy, V. P. Hydrogen Fluoride for the Synthesis of Alkyl Fluorides, in Synthetic Organofluorine Chemistry 1, Encyclopedia Series, Springer, Ed. J. Hu and T. Umemoto, 2018, 1-14; https://doi.org/10.
- Reddy, V. P.; Rasul, G.; Prakash, G. K. S. Ab initio structural studies of cyclobutylmethyl cations: effect of fluoroalkyl groups on the relative stability of the carbocations, Arkivoc 2018, 2, 233
- Editorial: Metabolic Disorders, Drug Development, Drug Design and Biomarkers; Aliev, G.; Cacabelos, R.; Reddy, V. P. Current Pharmaceutical Design, 2016, 22, 1-3.
- Neganova, M. E.; Klochkov, S. G.; Afanasieva, S. V.; Serkova, T. P.; Chudinova, E. S.; Bachurin, S. O.; Reddy, V. Prakash; Shevtsova, E. F.; Aliev, G. Neuroprotective effects of the securinine-analogues: identification of
Allomargaritarine as a lead compound, CNS & Neurol. Disorders, 2016,
15, 102-107. - Savvateeva, L. V.; Schwartz, A. M.; Gorshkova, L. B.; Gorokhovets, N. V.; Makarov, V. A.; Reddy, V. P.; Aliev, G.; Zamyatnin, A. A. Prophylactic Admission of an In Vitro Reconstructed Complexes of
Human Recombinant Heat Shock Proteins and Melanoma Antigenic
Peptides Activates Anti-Melanoma Responses in Mice, Curr. Mol. Med.
2015, 15, 462-468. - Iomdina, E. N.; Khoroshilova-Maslova, I. P.; Robustova, O. V.; Averina, O. A.; Kovaleva, N. A.; Aliev, G.; Reddy, V. P.; Zamyatinin, A. A.; Skulachev, M. V.; Senin, I, I.; Skulachev, V. P. Mitochondria-targeted Antioxidant SkQ1 Reverses Glaucomatous
Lesions in Rabbits, Front. Biosci. 2015, 20, 892-901. - Kosenko, E. A.; Beloushko, E. E.; Tikhonova, L. A.; Reddy, V. P.; Aliev, G.; Kaminsky, Y. G. Differential Up-Regulation of Ammonia Detoxifying Enzymes in
Cerebral Cortex, Cerebellum, Hippocampus, Striatum and Liver in
Hyperammonemia, CNS Neurol. Disord. Drug Targets 2014, 13(6),
1089-1095.