Isaac was born in Kerala, India. He received his B. Tech. and M. Tech. degrees in aerospace engineering from the Indian Institute of Technology, Madras. And he received his Ph. D. degree in aerospace engineering from Virginia Polytechnic Institute and State University.
Computational fluid dynamics (CFD) simulation of transport phenomena such as combustion, adsorption, multiphase flow and electrochemistry; Microfluidics; Lab-on-a-Chip; unsteady, low Reynolds number flows